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Department of Health Economics (DHE)

Antidepressant controlled trial for negative symptoms in schizophrenia (ACTIONS): A double-blind, placebo-controlled, randomised clinical trial

Date: 2013–2015
Funding: UK NIHR HTA
Collaborator(s): Centre for Mental Health, Imperial College London, UK
Information: Judit Simon (co-PI)

The negative symptoms of schizophrenia represent deficiencies in emotional responsiveness, motivation, socialization, speech, and movement. Persistent negative symptoms are held to account for much of the long-term morbidity and poor functional outcome of people with schizophrenia. This study sought to assess the potential benefit of a depression medication in this patient population. The DHE was involved in the economic evaluation of this intervention alongside the ACTIONS study.